Alligation Method

Workplace Applications

In daily practice, alligation method is applied consistently according to facility protocols and current evidence-based guidelines. Competency is maintained through annual skills validation, continuing education, and quality improvement participation.

Equipment & Tools

Mathematical method for calculating proportions when mixing two different concentrations to achieve a desired intermediate concentration. Alligation calculations tested on PTCB exam.

Related drug class: Benzodiazepines includes lorazepam, diazepam, alprazolam, midazolam. Mechanism: Enhance GABA-A receptor, increased chloride conductance, CNS depression.

Professional Standards

Professional standards governing alligation method in pharmacy:

USP 797 (USP): Sterile compounding standards: ISO 5 PEC within ISO 7 buffer area, BUD limits, garbing, environmental monitoring

Poison Prevention Packaging Act (CPSC): Child-resistant packaging required unless patient/prescriber requests non-CRC. Exceptions: sublingual NTG, oral contraceptives

Regulatory Context

Regulatory framework for alligation method in pharmacy:

Schedule II

High abuse potential with accepted medical use. Examples: oxycodone, fentanyl, morphine, amphetamine, methylphenidate. Storage: Double-locked, perpetual inventory, no refills, written/electronic Rx only

Schedule III

Moderate abuse potential. Examples: testosterone, ketamine, Tylenol with codeine. Storage: 5 refills in 6 months, written/oral/electronic Rx

Practical Example

Safety Considerations

Safety standards for alligation method in pharmacy practice are governed by Poison Prevention Packaging Act: Child-resistant packaging required unless patient/prescriber requests non-CRC. Exceptions: sublingual NTG, oral contraceptives

Enforcing agency: CPSC. Compliance is mandatory and subject to inspection.