Free USP <800> Hazardous Drugs Practice Questions

1. An "assessment of risk" under USP <800> allows alternative containment strategies for:

• Non-sterile HD handling (e.g., counting tablets) if certain conditions are met, such as using a dedicated ventilated containment device
• All hazardous drug compounding without any engineering controls
• Eliminating PPE requirements
• Skipping the decontamination step during routine cleaning

2. Under USP <800>, which type of ventilated cabinet must be externally vented (exhausted to the outside) when compounding hazardous drugs?

• Class II, Type B2 biological safety cabinet (100% exhaust to outside)
• Class I BSC (open-front, unrecirculated)
• A horizontal LAFW (recirculated)
• Any cabinet with HEPA filters, regardless of exhaust type

3. Per USP <800>, medical surveillance for personnel who handle hazardous drugs should include:

• A baseline health assessment before handling HDs, with follow-up evaluations as needed (e.g., after exposure incidents)
• Annual chest X-rays only
• Weekly blood tests
• No surveillance is required if PPE is worn

4. USP <800> requires that entities handling hazardous drugs maintain a list of all HDs based on:

• The current NIOSH list of antineoplastic and other hazardous drugs, reviewed at least every 12 months
• The pharmacy's own internal criteria, updated every 5 years
• The FDA Orange Book
• State board of pharmacy guidelines only

5. The correct order of surface treatment when cleaning a hazardous drug spill area is:

• Decontamination, then cleaning, then disinfection
• Disinfection, then decontamination, then cleaning
• Cleaning only
• Disinfection only