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TL;DR

Study the recognition, pathophysiology, and emergency management of sepsis and common infectious diseases. Early sepsis identification dramatically improves survival and is a critical paramedic competency.

By Valenke Exam Prep Team·Last updated 2026-06-03

Free Sepsis & Infectious Disease Practice Questions

NREMT Paramedic Certification · Medical / OB / GYN (Advanced)

This module covers Sepsis & Infectious Disease as part of the Medical / OB / GYN (Advanced) section, testing your understanding of core concepts and their practical application.

ExamNREMT Paramedic Certification
Pass Rate67%
Duration150 minutes
ModuleSepsis & Infectious Disease

Why Sepsis & Infectious Disease matters

Sepsis & Infectious Disease is a commonly tested topic on the NREMT Paramedic Certification because it covers fundamental knowledge required for competent professional practice.

Sample Practice Questions (5)

1. A patient with a known urinary tract infection presents with fever (102.5°F), heart rate of 110, respiratory rate of 24, and confusion. You suspect sepsis. What is the MOST important initial prehospital intervention?

  • Establish IV access and begin a fluid bolus of 30 mL/kg isotonic crystalloid
  • Administer broad-spectrum antibiotics in the field
  • Apply cold packs to reduce the fever before transport
  • Administer a vasopressor immediately to support blood pressure

2. During fluid resuscitation of a septic patient, which of the following is the recommended initial volume and type of fluid per the Surviving Sepsis Campaign?

  • 30 mL/kg of isotonic crystalloid (normal saline or lactated Ringer's) within the first hour
  • 10 mL/kg of colloid solution (albumin) over 4 hours
  • 500 mL of normal saline followed by reassessment over 6 hours
  • 5% dextrose in water (D5W) at a maintenance rate

3. Which of the following BEST defines sepsis?

  • A life-threatening organ dysfunction caused by a dysregulated host response to infection
  • Any bacterial infection in the bloodstream
  • An elevated white blood cell count with fever
  • An allergic reaction to an infectious agent

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4. Which of the following correctly describes the concept of "severe sepsis" as it was historically defined, and why the Sepsis-3 definitions eliminated this category?

  • Severe sepsis was sepsis with organ dysfunction; Sepsis-3 eliminated it because the new definition of sepsis itself requires organ dysfunction, making "severe sepsis" redundant
  • Severe sepsis was any infection with fever; it was eliminated because fever is not always present in sepsis
  • Severe sepsis was sepsis requiring ICU admission; it was eliminated because all sepsis patients require ICU care
  • Severe sepsis was sepsis with hypotension; it was eliminated and renamed septic shock

5. You are managing a septic shock patient who remains hypotensive despite 30 mL/kg crystalloid and a norepinephrine infusion titrated to 20 mcg/min. What is the MOST appropriate next step?

  • Add vasopressin 0.03 units/min as a second vasopressor, and consider stress-dose hydrocortisone
  • Switch to phenylephrine as the sole vasopressor
  • Administer an additional 3 liters of crystalloid rapidly
  • Discontinue norepinephrine and start dopamine instead

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Frequently Asked Questions

How many Sepsis & Infectious Disease questions are on the NREMT Paramedic Certification?
The Medical / OB / GYN (Advanced) section, which includes Sepsis & Infectious Disease, typically represents a significant portion of the exam. Focus on understanding core concepts rather than memorizing exact question counts, as the exam uses adaptive testing.
What is the best way to study Sepsis & Infectious Disease?
Use active recall and spaced repetition rather than passive reading. Practice with realistic exam questions, review explanations for both correct and incorrect answers, and focus on understanding the reasoning behind each concept.
What topics within Sepsis & Infectious Disease should I focus on most?
Focus on the concepts that appear in our practice questions and any areas where you consistently score below 70%. The adaptive practice mode will automatically target your weak areas for efficient study.